The Iduronate 2 sulfatase antibody from Wuhan Fine Biotech Co., Ltd. is a Mouse Monoclonal antibody to IDS, and Iduronate 2-sulfatase. This antibody recognizes Homo Sapiens, and Human antigen. The Iduronate 2 sulfatase antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181)